Acute Stress Ulceration

Stress controversies: post-traumatic stress disorder, hippocampal volume, gastroduodenal ulceration*.

Stress in mammals triggers a neuroendocrine response mediated by the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. Increased activity of these two systems induces behavioural, cardiovascular, endocrine and metabolic cascades that enable the individual to fight or flee and cope with the stress. Our understanding of stress and stress-response mechanisms is generally robust...

Gastroprotective role of bioflavonoid silymarin in animal model of acute cold-restraint stress induced gastric ulceration

Introduction: Imbalance between the aggressive and defensive factors and presence of acidpepsin is supposed to play a major role in aetiopathogenesis of peptic ulcer disease. Recently, role of oxidative free radicals have been implicated in mediating cold-restraint stress, H.pylori, NSAID induced gastric injury. Objective: The present study was undertaken to evaluate the possible role of antiox...

Stress ulceration: prevalence, pathology and association with adverse outcomes

Prevention of stress ulceration: current trends in critical care.

OBJECTIVE To identify the level of current intensivist's knowledge regarding risk assessment and intensive care unit (ICU) clinical practice pertaining to stress-related mucosal bleeding, including pharmacologic approaches for stress ulcer prevention. DESIGN A nationwide survey of critical care physicians. STUDY POPULATION Two thousand random physician members of the Society of Critical Car...

Mortality Associated With Acute Charcot Foot and Neuropathic Foot Ulceration

OBJECTIVE To compare the mortality of patients with an acute Charcot foot with a matched population with uninfected neuropathic foot ulcers (NFUs). RESEARCH DESIGN AND METHODS Data were extracted from a specialist departmental database, supplemented by hospital records. The findings were compared with the results of earlier populations with Charcot foot and uninfected NFUs managed from 1980. ...